OUR APPROACH
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Our Discovery Engine

A proprietary in-house discovery platform enables us to see the real-world interaction between drug and target in rapid, sequential, structural SNÅPshots. With each SNÅP, we bring speed, clarity, and focus to structure-based drug design.

Driven by clear patient needs

Using our SNÅP Discovery Engine, we drive towards innovative molecular structures that can overcome mechanisms of resistance to currently available treatments and improve the lives of patients with cancer.

Target is inhibited by first-generation drug

 

Resistance mutation emerges blocking binding of the drug

 

Tyra drug designed to accommodate new active site architecture

 

Wild type and mutated form of target is inhibited by Tyra drug

 

Quick and routine data generation

Full structural SNÅPshots for our discovery compounds are obtained in as little as 7 days, rather than weeks to months. This enables us to rapidly iterate on designs week after week with a clear line of sight into how each modification moves us closer to our goal.

full structural SNÅPshots in as little as 7 days

Focused generation of empirical (real-world) data

Our engine prioritizes a select number of critical assays, with an emphasis on datasets that can drive precise design refinements. Together, this data forms a full picture or structural “SNÅPshot” for each discovery compound that reveals clear opportunities to refine its molecular design, down to a tenth of an angstrom (Å).

Experience translated into innovation

We have distilled decades of experience into process optimizations and innovations. Our advancements to the art of protein crystallography are key to reducing the time-to-structure from multiple weeks to days:

Multi-species crystal seed stocks rapidly induce crystallization

Proprietary additives in sparse matrix chemical screens enhance crystal packing and growth

Crystals are immortalized via chemical stabilization. Banked crystals are ready for compound addition.

Immortalized crystals are fed back into multi-species crystal seed stocks

Purpose-built medicines

Leveraging insights from rapid, sequential SNÅPshots, we move with angstrom-level precision towards selective inhibitors that may deliver deeper, more durable responses for patients with cancer.